Om ett fysiskt beroende har uppkommit kommer ett plötsligt avbrott i behandlingen att leda until abstinenssymtom.Należy zachować ostrożność podczas stosowania preparatu z lekami wpływającymi na aktywność izoenzymu 3A4 cytochromu P450. Leki hamujące aktywność tego izoenzymu (np.Należy wówczas stosować najmniejszą skuteczną dawkę
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